Mercury + GABAB → Mg2+ Deficit → Ca2+ Overload → Stiffness

Biochemical Pathway Report
1. Mercury Toxicity Exposure

Heavy metal accumulation from Mercury (Hg) begins a destructive cascade in the central nervous system by targeting high-affinity sulfhydryl groups.

2. GABAB Receptor Downregulation

Chronic exposure selectively degrades and alters the expression of structural GABAB receptors, crippling the brain's baseline inhibitory control networks.

3. Intracellular Magnesium Deficit

The failure of inhibitory signaling disrupts normal ion homeostasis, leading to a profound intracellular Magnesium (Mg2+) deficit inside the cellular matrix.

4. Calcium Channel Overload

Without sufficient magnesium to block the gates, NMDA channels remain open, prompting a massive, toxic Calcium (Ca2+) overload.

5. Physical Muscle Stiffness & Hypertonia

Continuous calcium influx forces relentless actin-myosin cross-bridging, causing permanent muscle tone elevation, stiffness, and failure to relax.

6. Glycine Modulation Pathway

Therapeutic application of Glycine serves to stimulate alternate inhibitory paths, helping to re-establish polarization and damp down systemic hyperexcitability.