BRIGHTON AI Based on the provided information, there is no direct evidence that Nicotinamide N-methyltransferase (NNMT) levels increase with age in the body. While NNMT is involved in the metabolism of nicotinamide (niacinamide), its role in aging or age-related health issues is not well-established. GOOGLE AI As a person ages, the activity and expression of the enzyme Nicotinamide N-methyltransferase (NNMT) tend to increase, and this has been linked to the development of various age-related health issues However, whether individuals should take action to decrease NNMT is a complex issue, as more research is needed and NNMT may have both beneficial and harmful effects depending on the tissue and context